Intronic miR-3151 Within BAALC Drives Leukemogenesis by Deregulating the TP53 Pathway
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چکیده
منابع مشابه
MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.
The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a top candidate for targeted treatment strategies in MM and PTC. We show that BRAF mutations in bot...
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Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied mi...
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Ann-Kathrin Eisfeld,1 Guido Marcucci,1 Kati Maharry,1,2 Sebastian Schwind,1 Michael D. Radmacher,1,2 Deedra Nicolet,1,2 Heiko Becker,1 Krzysztof Mrózek,1 Susan P. Whitman,1 Klaus H. Metzeler,1 Jason H. Mendler,1 Yue-Zhong Wu,1 Sandya Liyanarachchi,1 Ravi Patel,1 Maria R. Baer,3 Bayard L. Powell,4 Thomas H. Carter,5 Joseph O. Moore,6 Jonathan E. Kolitz,7 Meir Wetzler,8 Michael A. Caligiuri,1 Ric...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2014
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.2004762